Rappsilber Laboratory – Innovation in protein mass spectrometry

LATEST PUBLICATIONS

Co-regulation map of the human proteome enables identification of protein functions

Nature Biotechnology, 2019

by Georg Kustatscher, on 04 November 2019, in Machine learning, Publication, Software

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

Nature Communications, 2019

by Juri Rappsilber, on 11 July 2019, in Crosslinking, Publication

Quantitative Photo-crosslinking Mass Spectrometry Revealing Protein Structure Response to Environmental Changes

Analytical Chemistry, 2019

by Andrea Graziadei, on 17 June 2019, in Crosslinking, Method development, Publication, Quantitation

A folded conformation of MukBEF and cohesin

Nature Structural & Molecular Biology, 2019

by Ludwig Sinn, on 04 March 2019, in Collaboration highlights, Crosslinking, Publication, Structural Biology (application)

Sequential Digestion with Trypsin and Elastase in Cross-Linking Mass Spectrometry.

Analytical Chemistry, 2019

by Therese Dau, on 28 February 2019, in Crosslinking, Method development, Publication

LAB NEWS

Rappsilber laboratoryFollow

Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible and useful.

Rappsilber laboratory @RappsilberLab·

18 Nov

We got a new #nanoAKTA system installed in our lab and we are very much excited about it 🥳 #nanoAKTAchallenge @GEHealthcare

Reply on Twitter 1196380804265521152 Retweet on Twitter 11963808042655211521 Like on Twitter 119638080426552115213 Twitter 1196380804265521152

Rappsilber laboratory @RappsilberLab·

5 Nov

We are very excited to share our very recent publication with you 🥳 https://www.nature.com/articles/s41587-019-0298-5 #MachineLearning #systemsbiology #proteomics

Reply on Twitter 1191728741422174209 Retweet on Twitter 11917287414221742098 Like on Twitter 119172874142217420934 Twitter 1191728741422174209

Rappsilber laboratory @RappsilberLab·

4 Nov

A fantastic collaboration on the elucidation of the structure of the Fanconi anaemia core complex. The study also highlights the complementary power of cryo-EM and mass spectrometry methods. Much more to come! @lapassmore @Fjoreilly89 https://www2.mrc-lmb.cam.ac.uk/decade-long-collaboration-results-in-the-first-structure-of-the-fanconi-anaemia-core-complex/

Reply on Twitter 1191309863516876800 Retweet on Twitter 11913098635168768004 Like on Twitter 119130986351687680013 Twitter 1191309863516876800

Rappsilber laboratory @RappsilberLab·

4 Oct

Creating new organic compounds for cross-linking mass spectrometry here at the @RappsilberLab. Let the chemistry party begin @ana_aperezl 🥳

Reply on Twitter 1180047813226516481 Retweet on Twitter 11800478132265164812 Like on Twitter 118004781322651648111 Twitter 1180047813226516481

Retweet on Twitter Rappsilber laboratory Retweeted

Mol Syst Biol @MolSystBiol·

30 Sep

09/2019 Issue --> http://bit.ly/2mNNGIR
Decoding p53 dynamics, ESC differentiation, role of paralogs in robustness, #proteomics, #transcription, #Qbio, #evolution
Cover (by @skrahl): assembling protein complexes with cross-linking #MassSpectrometry from @RappsilberLab

Reply on Twitter 1178564519804751873 Retweet on Twitter 117856451980475187321 Like on Twitter 117856451980475187354 Twitter 1178564519804751873

Funding

We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.