MartaTheir structure and interactions define cellular processes and are therefore critical
to our understanding how cells work and how diseases can be cured.
Proteins are the active ingredient of life Our mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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LaptopOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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Sven&ChristianOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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EasysprayOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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LAB NEWS

Happy to share our new preprint! We provide a methodological understanding of the key parameters that govern crosslink identification and hope to pave the way for simplified workflows that a wider number of labs can use. https://www.biorxiv.org/content/10.1101/2021.11.23.469675v1

Protein-protein interactions (PPIs) are on the basis of life yet their discovery is complicated - CLMS offers an exciting opportunity for their study but error control remained controversial (1/10)

Our latest research on the use of deep learning for retention time prediction in crosslinking mass spectrometry has just been published with @SpringerNature in @NatureComms. Find out more here: https://www.nature.com/articles/s41467-021-23441-0
@RappsilberLab @SvenHGiese @LrSinn

XiView now produces outputs for visualizing crosslink data and EM densities - @UCSFChimeraX pseudobond files, @jankosinski 's XlinkAnalyzer files. Upload a structure and check out the new 3d export tab at https://xiview.org

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Funding

We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.