We present a systematic analysis providing a statistical description of the advantages of MS-cleavable crosslinkers. Using datasets from different labs, we clarify the mechanisms by which these improve crosslinked peptide detection. https://pubs.acs.org/doi/10.1021/acs.analchem.1c05266

Understudied proteins are a big obstacle for biomedical research. Most research to date focuses on a limited set of increasingly well-known proteins, so we are launching the Understudied Proteins Initiative. Find out more @naturemethods (https://rdcu.be/cNbFd) and ...

Happy to share our pre-print "SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff" - we harness crosslinking-MS to characterize the protein-protein interaction network of SARS-CoV-2 Nsp1 in translational repression.
https://doi.org/10.1101/2022.02.10.479924

We are proud to share our review “Leveraging crosslinking mass spectrometry in structural and cell biology” https://www.cell.com/structure/fulltext/S0969-2126(21)00419-6 for an upcoming @structure_CP special issue. (1/2)

Happy to share our new preprint! We provide a methodological understanding of the key parameters that govern crosslink identification and hope to pave the way for simplified workflows that a wider number of labs can use. https://www.biorxiv.org/content/10.1101/2021.11.23.469675v1