LATEST PUBLICATIONS

Co-regulation map of the human proteome enables identification of protein functions

Nature Biotechnology, 2019
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by Georg Kustatscher, on 04 November 2019, in Machine learning, Publication, Software

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

Nature Communications, 2019
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by Juri Rappsilber, on 11 July 2019, in Crosslinking, Publication

Quantitative Photo-crosslinking Mass Spectrometry Revealing Protein Structure Response to Environmental Changes

Analytical Chemistry, 2019
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by Andrea Graziadei, on 17 June 2019, in Crosslinking, Method development, Publication, Quantitation

A folded conformation of MukBEF and cohesin

Nature Structural & Molecular Biology, 2019
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by Ludwig Sinn, on 04 March 2019, in Collaboration highlights, Crosslinking, Publication, Structural Biology (application)

Sequential Digestion with Trypsin and Elastase in Cross-Linking Mass Spectrometry.

Analytical Chemistry, 2019
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by Therese Dau, on 28 February 2019, in Crosslinking, Method development, Publication

LAB NEWS

Rappsilber laboratoryFollow

Our mission is to develop approaches to study protein structure and interactions in cells and make them universally accessible and useful.

Rappsilber laboratory
RappsilberLabRappsilber laboratory@RappsilberLab·
17 Jan

We are currently looking for feedback on the useability and functionality of the xiVIEW visualization software. If you got some time, please participate 😊 thank you! https://edinburgh.onlinesurveys.ac.uk/xiview-usability

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MRC_LMSMRC LMS@MRC_LMS·
8 Jan

We are delighted to welcome @FJ_OReilly of @RappsilberLab @TUBerlin to the MRC LMS later today. Francis will be giving a seminar talk about crosslinking #MassSpectroscopy for #StructuralBiology studies

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RappsilberLabRappsilber laboratory@RappsilberLab·
22 Nov

In Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria https://pubs.acs.org/doi/10.1021/acs.jproteome.9b00541#.Xde73c9jXLs.twitter

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RappsilberLabRappsilber laboratory@RappsilberLab·
18 Nov

We got a new #nanoAKTA system installed in our lab and we are very much excited about it 🥳 #nanoAKTAchallenge @GEHealthcare

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RappsilberLabRappsilber laboratory@RappsilberLab·
5 Nov

We are very excited to share our very recent publication with you 🥳 https://www.nature.com/articles/s41587-019-0298-5 #MachineLearning #systemsbiology #proteomics

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Funding

We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.