
to our understanding how cells work and how diseases can be cured.
and interactions in cells and make them universally accessible.


and interactions in cells and make them universally accessible.


and interactions in cells and make them universally accessible.


and interactions in cells and make them universally accessible.


LATEST PUBLICATIONS
Improved Peptide Backbone Fragmentation Is the Primary Advantage of MS-Cleavable Crosslinkers
LAB NEWS
Happy to share our new preprint, "Protein Complexes in Bacillus subtilis by AI-assisted structural proteomics"! https://www.biorxiv.org/content/10.1101/2022.07.26.501605v1
Fantastic collaboration with the @JorgStulke lab!
This calls for citizens science by scientists! More info on understudied proteins at https://www.nature.com/articles/s41592-022-01454-x
Help solve the understudied proteins challenge. Vote for how well studied a randomly chosen protein is. https://understudiedproteins.org/survey
#CitizensScienceForScientists
We present a systematic analysis providing a statistical description of the advantages of MS-cleavable crosslinkers. Using datasets from different labs, we clarify the mechanisms by which these improve crosslinked peptide detection. https://pubs.acs.org/doi/10.1021/acs.analchem.1c05266
Understudied proteins are a big obstacle for biomedical research. Most research to date focuses on a limited set of increasingly well-known proteins, so we are launching the Understudied Proteins Initiative. Find out more @naturemethods (https://rdcu.be/cNbFd) and ...
Happy to share our pre-print "SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff" - we harness crosslinking-MS to characterize the protein-protein interaction network of SARS-CoV-2 Nsp1 in translational repression.
https://doi.org/10.1101/2022.02.10.479924
Funding
We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.