MartaTheir structure and interactions define cellular processes and are therefore critical
to our understanding how cells work and how diseases can be cured. Proteins are the active ingredient of life Our mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible. Learn more LaptopOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible. Learn more Sven&ChristianOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible. Learn more EasysprayOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible. Learn more

LATEST PUBLICATIONS

Ultraviolet Photodissociation of Tryptic Peptide Backbones at 213 nm

Lars Kolbowski, Adam Belsom, Juri Rappsilber Journal of the American Society for Mass Spectrometry, 2020 https://doi.org/10.1021/jasms.0c00106 We analyzed the backbone fragmentation behavior of tryptic peptides of a four protein mixture and of E. coli lysate subjected to Ultraviolet Photodissociation (UVPD) at 213 nm on a commercially available UVPD-equipped tribrid mass spectrometer. We obtained 15,178 unique
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by rapplab-admin, on 30 April 2020, in Method development, MS development, Publication

The structure of human thyroglobulin

Nature, 2020
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by Ludwig Sinn, on 05 February 2020, in Collaboration highlights, Crosslinking, Publication, Structural Biology (application)

Co-regulation map of the human proteome enables identification of protein functions

Nature Biotechnology, 2019
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by Georg Kustatscher, on 04 November 2019, in Machine learning, Publication, Software

Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

Nature Communications, 2019
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by Juri Rappsilber, on 11 July 2019, in Crosslinking, Publication

Quantitative Photo-crosslinking Mass Spectrometry Revealing Protein Structure Response to Environmental Changes

Analytical Chemistry, 2019
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by Andrea Graziadei, on 17 June 2019, in Crosslinking, Method development, Publication, Quantitation

LAB NEWS

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EMBLEventsEMBL Events@EMBLEvents·
3 Jul

Welcome everyone to #EMBLInfectionResearch!

@JEPaquetEU from @EUScienceInnov @EU_Commission opened the conference with an interesting introduction👏

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MolSystBiolMol Syst Biol@MolSystBiol·
3 Jul

Very excited to hear so many talks on SARS-CoV-2 COVID-19 research at the @embl @EMBLEvents
#EMBLInfectionResearch conference https://www.embl.de/training/events/2020/EID20-01/index.html

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RappsilberLabRappsilber laboratory@RappsilberLab·
26 May

[Preprint] We experimentally demonstrate reliable FDR estimation in large scale cross-linking MS studies using the target-decoy approach. Great Work @swantjelenz LudwigSinn @FJ_OReilly https://www.biorxiv.org/content/10.1101/2020.05.25.114256v1 😊

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RappsilberLabRappsilber laboratory@RappsilberLab·
15 May

A thorough analysis of Ultraviolet Photodissociation of tryptic peptide backbones at 213 nm. @LKolbowski @adambelsom 😊https://pubs.acs.org/doi/10.1021/jasms.0c00106

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RappsilberLabRappsilber laboratory@RappsilberLab·
2 Mar

We are happy to see our preprint on the architecture of coupled transcription and translation inside cells online 🥳 Combining the power of whole cell crosslinking-MS, Cryo-ET, and integrative modeling. https://www.biorxiv.org/content/10.1101/2020.02.28.970111v1

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Funding

We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.