MartaTheir structure and interactions define cellular processes and are therefore critical
to our understanding how cells work and how diseases can be cured.
Proteins are the active ingredient of life Our mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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LaptopOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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Sven&ChristianOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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EasysprayOur mission is to develop approaches to study protein structure
and interactions in cells and make them universally accessible.
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LAB NEWS

Happy to share our new preprint, "Protein Complexes in Bacillus subtilis by AI-assisted structural proteomics"! https://www.biorxiv.org/content/10.1101/2022.07.26.501605v1
Fantastic collaboration with the @JorgStulke lab!

We present a systematic analysis providing a statistical description of the advantages of MS-cleavable crosslinkers. Using datasets from different labs, we clarify the mechanisms by which these improve crosslinked peptide detection. https://pubs.acs.org/doi/10.1021/acs.analchem.1c05266

Understudied proteins are a big obstacle for biomedical research. Most research to date focuses on a limited set of increasingly well-known proteins, so we are launching the Understudied Proteins Initiative. Find out more @naturemethods (https://rdcu.be/cNbFd) and ...

Happy to share our pre-print "SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff" - we harness crosslinking-MS to characterize the protein-protein interaction network of SARS-CoV-2 Nsp1 in translational repression.
https://doi.org/10.1101/2022.02.10.479924

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Funding

We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.