In Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria

We got a new #nanoAKTA system installed in our lab and we are very much excited about it 🥳 #nanoAKTAchallenge @GEHealthcare

We are very excited to share our very recent publication with you 🥳 #MachineLearning #systemsbiology #proteomics

A fantastic collaboration on the elucidation of the structure of the Fanconi anaemia core complex. The study also highlights the complementary power of cryo-EM and mass spectrometry methods. Much more to come! @lapassmore @Fjoreilly89

Creating new organic compounds for cross-linking mass spectrometry here at the @RappsilberLab. Let the chemistry party begin @ana_aperezl 🥳

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We gratefully acknowledge support by our funders especially the Wellcome Trust for their willingness to fund us when our vision was daring but the prospects of ever reaching our goals still far remote. We are also deeply indebted to Edinburgh for providing a very supportive research environment and many great colleagues for being the way they are. This allowed us to ultimately overcome the key challenges of our approach. We also thank the many gifted students of Biotechnology at the TU Berlin for their curiosity and interest in technology development and the TU Berlin for providing a space to tune and scale our approach.